Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
نویسندگان
چکیده
منابع مشابه
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.
Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio-economic challenges, as well as opportunities, for individuals, families, governments and societies. The prevailing biomedical strategy for reducing the healthcare impact of population ageing has been 'compression of morbidity' and, more recently, to increase healthspan, both of which seek ...
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Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability. This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences. Superimposed on this setting are the adults now reaching traditional retiremen...
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For decades, researchers in the biology of aging have focused on defining mechanisms that modulate aging by primarily studying a single metric, sometimes described as the "gold standard" lifespan. Increasingly, geroscience research is turning towards defining functional domains of aging such as the cardiovascular system, skeletal integrity, and metabolic health as being a more direct route to u...
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Population aging is unprecedented, without parallel in human history, and the 21st century will witness even more rapid aging than did the century just past. Improvements in public health and medicine are having a profound effect on population demographics worldwide. By 2017, there will be more people over the age of 65 than under age 5, and by 2050, two billion of the estimated nine billion pe...
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At the beginning of the 20 century the names of deadly childhood diseases were whispered in fear. Everyone knew a family visited by the shadow of tuberculosis, rickets, polio or smallpox. Chickenpox and rubella brought their own forms of misery. Each disease presented in different ways, affected different organs and had distinct prognoses. Many of us will remember the endless cycles of bake sal...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2015
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2014.282665